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Engineering a Clinically Translatable Bioartificial Pancreas to Treat Type I Diabetes

Trends in Biotechnology, ISSN: 0167-7799, Vol: 36, Issue: 4, Page: 445-456
2018
  • 67
    Citations
  • 0
    Usage
  • 147
    Captures
  • 1
    Mentions
  • 11
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    67
  • Captures
    147
  • Mentions
    1
    • Blog Mentions
      1
      • Blog
        1
  • Social Media
    11
    • Shares, Likes & Comments
      11
      • Facebook
        11

Review Description

Encapsulating, or immunoisolating, insulin-secreting cells within implantable, semipermeable membranes is an emerging treatment for type 1 diabetes. This approach can eliminate the need for immunosuppressive drug treatments to prevent transplant rejection and overcome the shortage of donor tissues by utilizing cells derived from allogeneic or xenogeneic sources. Encapsulation device designs are being optimized alongside the development of clinically viable, replenishable, insulin-producing stem cells, for the first time creating the possibility of widespread therapeutic use of this technology. Here, we highlight the status of the most advanced and widely explored implementations of cell encapsulation with an eye toward translating the potential of this technological approach to medical reality.

Bibliographic Details

Orive, Gorka; Emerich, Dwaine; Khademhosseini, Ali; Matsumoto, Shinichi; Hernández, R M; Pedraz, J L; Desai, Tejal; Calafiore, Riccardo; de Vos, Paul

Elsevier BV

Biochemistry, Genetics and Molecular Biology; Chemical Engineering

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