Genome organization influences partner selection for chromosomal rearrangements
Trends in Genetics, ISSN: 0168-9525, Vol: 27, Issue: 2, Page: 63-71
2011
- 39Citations
- 173Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations39
- Citation Indexes39
- 39
- CrossRef37
- Captures173
- Readers173
- 173
Review Description
Chromosomal rearrangements occur as a consequence of the erroneous repair of DNA double-stranded breaks, and often underlie disease. The recurrent detection of specific tumorigenic rearrangements suggests that there is a mechanism behind chromosomal partner selection involving the shape of the genome. With the advent of novel high-throughput approaches, detailed genome integrity and folding maps are becoming available. Integrating these data with knowledge of experimentally induced DNA recombination strongly suggests that partner choice in chromosomal rearrangement primarily follows the three-dimensional conformation of the genome. Local rearrangements are favored over distal and interchromosomal rearrangements. This is seen for neutral rearrangements, but not necessarily for rearrangements that drive oncogenesis. The recurrent detection of tumorigenic rearrangements probably reflects their exceptional capacity to confer growth advantage to the rare cells that contain them. The abundant presence of neutral rearrangements suggests that somatic genome variation is also common in healthy tissue.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0168952510002210; http://dx.doi.org/10.1016/j.tig.2010.11.001; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79151478493&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/21144612; https://linkinghub.elsevier.com/retrieve/pii/S0168952510002210; https://dx.doi.org/10.1016/j.tig.2010.11.001
Elsevier BV
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