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A Circuit-Based Information Approach to Substance Abuse Research

Trends in Neurosciences, ISSN: 0166-2236, Vol: 44, Issue: 2, Page: 122-135
2021
  • 22
    Citations
  • 0
    Usage
  • 65
    Captures
  • 0
    Mentions
  • 10
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    22
  • Captures
    65
  • Social Media
    10
    • Shares, Likes & Comments
      10
      • Facebook
        10

Review Description

Recent animal research on substance-use disorders (SUDs) has emphasized learning models and the identification of ‘addiction-prone’ animals. Meanwhile, basic neuroscientific research has elucidated molecular, cellular, and circuit functions with increasing sophistication. However, SUD-related research is hampered by continued arguments over which animal models are more ‘addiction like’, as well as the facile assignment of behaviors to a given brain region and vice versa. We argue that SUD-related research would benefit from a ‘bottom-up’ approach including: (i) the characterization of different brain circuits to understand their normal function as well as how they respond to drugs and contribute to SUDs; and (ii) a focus on the use patterns and neurobiological effects of different substances to understand the range of critical SUD-related in vivo phenotypes.

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