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Effects of malachite green (MG) and its major metabolite, leucomalachite green (LMG), in two human cell lines

Toxicology in Vitro, ISSN: 0887-2333, Vol: 19, Issue: 7, Page: 853-858
2005
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Article Description

Malachite green (MG) is still illegally used as a fungicide in aquaculture. In fish it is absorbed and metabolised to its major reduced metabolite, leucomalachite green (LMG). This latter represents the main residue found in fish tissues and may persist for several months. Since MG, suspected to act as a tumour promoter in vitro and in vivo, might be also present as a residue in fish, the present study was undertaken to ascertain the in vitro toxicity of both compounds in two human tumour cell lines (Caco-2 and HEp-2).

Bibliographic Details

Stammati, Annalaura; Nebbia, Carlo; Angelis, Isabella De; Albo, Alessandra Giuliano; Carletti, Monica; Rebecchi, Claudia; Zampaglioni, Franco; Dacasto, Mauro

Elsevier BV

Pharmacology, Toxicology and Pharmaceutics

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