Stem cells in myelotoxicity
Toxicology, ISSN: 0300-483X, Vol: 267, Issue: 1, Page: 112-117
2010
- 17Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef14
- Captures24
- Readers24
- 24
Article Description
Myelotoxicity describes bone marrow failure due to adverse effect of xenobiotic on hematopoiesis. Hematopoiesis is a complex system in which pluripotent hematopoietic stem cells (PHSCs) differentiate into many highly specialized circulating blood cells involving the interaction of many cell types as well as the interaction of local and systemic growth factors. With respect to blood cell formation, two functional systems must be considered: the hematopoietic stem cells (PHSCs) and the progenitor cells, on one hand, and the stromal cells, which constitute the hematopoietic environment niche, on the other hand. There are three types of assays for hematopoietic progenitor clonogenic assays useable in myelotoxicology: CFU-GM assay for Colony Forming Unit Granulocyte and Macrophage, BFU-E assay for Burst Forming Unit Erythroid, and CFU-MK assay for Colony Forming Unit Megakaryocyte from several species as well as from murine as from mammalian and human. Clonogenic assays have been used to detect myelotoxicity induced by chemicals, drug, food and environmental contaminants. Designs and applications are described in this review.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0300483X09005356; http://dx.doi.org/10.1016/j.tox.2009.10.031; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=71849111471&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/19883721; https://linkinghub.elsevier.com/retrieve/pii/S0300483X09005356; https://dx.doi.org/10.1016/j.tox.2009.10.031
Elsevier BV
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