Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats
Toxicology Letters, ISSN: 0378-4274, Vol: 370, Page: 35-41
2022
- 15Citations
- 51Captures
- 1Mentions
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Metrics Details
- Citations15
- Citation Indexes15
- 15
- Captures51
- Readers51
- 51
- Mentions1
- News Mentions1
- 1
Most Recent News
Findings from University of Bergen in the Area of Life Science Reported (Intestinal Permeability and Gene Expression After Polyethylene and Polyamide Microplastic Ingestion In Wistar Rats)
2022 NOV 30 (NewsRx) -- By a News Reporter-Staff News Editor at Gastroenterology Daily News -- Investigators publish new report on Life Science. According to
Article Description
Microplastic particles are ubiquitous in the environment. However, little is known about their uptake and effects in humans or mammalian model organisms. Here, we studied the effects of pristine polyamide (15–20 µm) and polyethylene (40–48 µm) particles after oral ingestion in rats. The animals received feed containing microplastic particles (0.1% polyamide or polyethylene, or a mixture of both polymers) or a control diet without microplastic particles, for 5 weeks. The permeability of the duodenum was investigated in an Ussing chamber, whereas gene expression and concentration of tight junction proteins were measured in gut tissue and plasma. Microplastic particles were quantified by pyrolysis-gas chromatography/mass spectrometry in rats’ feces. Rats fed with microplastic particles had higher duodenal permeability. Expression of gene coding for the tight junction protein occludin (OCLN) was higher in PE treated animals compared to control or the PA group. No changes in the expression of the gene coding for zonula occludens protein 1 were detected. Occludin protein concentrations were below the limit of detection of the applied method in both gut and plasma. Zonula occludens protein 1 concentrations in the gut were significantly higher in groups exposed to PA and PE as compared to control, while zonula occludens protein 1 concentrations in plasma did not show significant changes. These results demonstrated that short-term exposure to a dose of 0.1% (w/w) microplastic particles in feed had limited effects on duodenal permeability, expression of pro-inflammatory protein genes and tight junction protein genes in the duodenum.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0378427422009961; http://dx.doi.org/10.1016/j.toxlet.2022.09.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85138156619&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36089169; https://linkinghub.elsevier.com/retrieve/pii/S0378427422009961; https://dx.doi.org/10.1016/j.toxlet.2022.09.002
Elsevier BV
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