Rapid in-situ synthesis of metal organic frameworks for biosensors

Throughout the past ten years, metal-organic frameworks (MOFs) represent a class of coordination polymers characterized by high porosity and structural flexibility, and are increasingly used in biochemical analysis. However, largely due to the extremely low content of biomolecules, the transferability and support between MOFs material and sensing substrate are crucial for sensing sensitivity and stability, which directly affect their practical applications. Rapid in-situ MOF synthesis strategy is very important, which usually involves the direct growth of MOFs onto the sensing substrate in a "one-pot" process for simple, fast, portable and ideally large-scale preparation. This review focuses on the most current developments in the field of using MOFs produced quickly in-situ for highly sensitive detection of tiny amounts of protein, glucose, dopamine, ascorbic acid and uric acid by electrochemical, fluorescence, Raman, colorimetric sensing and microfluidics techniques.