Efficacy and side effects of praziquantel treatment against Schistosoma haematobium infection among primary school children in Zimbabwe
Transactions of the Royal Society of Tropical Medicine and Hygiene, ISSN: 0035-9203, Vol: 102, Issue: 8, Page: 759-766
2008
- 59Citations
- 10Usage
- 90Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations59
- Citation Indexes58
- 58
- CrossRef42
- Policy Citations1
- 1
- Usage10
- Abstract Views10
- Captures90
- Readers90
- 90
- Mentions1
- News Mentions1
- 1
Most Recent News
Worm Infestation and Child Health in Zimbabwe; Zimworms
STUDY INFORMATION OFFICIAL TITLE: Analysis on the Burden of Helminths-plasmodium Polyparasitism, Impact on Anaemia and Effects of Integrated School Based Parasite Control and Health Education
Article Description
We examined the efficacy of praziquantel against Schistosoma haematobium among primary school children during a school-based deworming programme in the Burma Valley commercial farming area and the Nyamaropa rural areas in Zimbabwe, where the disease is highly endemic. Among 767 individuals infected with S. haematobium, 675 (88.0%) received treatment. Two single oral doses of 40 mg/kg praziquantel were given 6 weeks apart. Of the 675 participants, heavy infection intensity was more common in males than females (χ 2 = 6.61, P = 0.010). Six weeks later, 624 participants (92.4%) were successfully followed up. The overall cure rate was 88.5% and the egg reduction rate was 98.2%. The highest cure rate was among those individuals with light infection. Seventy-two individuals remained infected at 6 weeks post treatment, among which 3 and 69 individuals had heavy and light infection, respectively. Forty-six of these children resolved following a second round of treatment at 6 weeks follow-up. Of the remaining children successfully followed-up, 22 resolved after a third round of treatment 6 months later. A wide range of observed mild and transient side effects were not associated with egg intensity. The parasitological cure rate was not associated with gender or age. Our study demonstrates that praziquantel is efficacious against S. haematobium in Zimbabwe, although low levels of persistent infection warrant further investigation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0035920308001089; http://dx.doi.org/10.1016/j.trstmh.2008.03.010; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=46249104637&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/18486169; https://academic.oup.com/trstmh/article-lookup/doi/10.1016/j.trstmh.2008.03.010; https://hsrc.himmelfarb.gwu.edu/sphhs_global_facpubs/1128; https://hsrc.himmelfarb.gwu.edu/cgi/viewcontent.cgi?article=2127&context=sphhs_global_facpubs; https://dx.doi.org/10.1016/j.trstmh.2008.03.010; https://academic.oup.com/trstmh/article-abstract/102/8/759/1895826?redirectedFrom=fulltext; https://rti.pure.elsevier.com/en/publications/87062c25-75a1-48e2-a6c6-e6803fb97a90; https://academic.oup.com/trstmh/article/102/8/759/1895826/Efficacy-and-side-effects-of-praziquantel; https://academic.oup.com/trstmh/article-pdf/102/8/759/5355109/102-8-759.pdf; https://academic.oup.com/trstmh/article/102/8/759/1895826; http://trstmh.oxfordjournals.org/cgi/doi/10.1016/j.trstmh.2008.03.010; http://trstmh.oxfordjournals.org/lookup/doi/10.1016/j.trstmh.2008.03.010; https://trstmh.oxfordjournals.org/content/102/8/759; http://trstmh.oxfordjournals.org/content/102/8/759
Oxford University Press (OUP)
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