Comparison of a fimbrial versus an autotransporter display system for viral epitopes on an attenuated Salmonella vaccine vector
Vaccine, ISSN: 0264-410X, Vol: 25, Issue: 9, Page: 1626-1633
2007
- 18Citations
- 34Captures
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Metrics Details
- Citations18
- Citation Indexes17
- CrossRef17
- 16
- Patent Family Citations1
- Patent Families1
- Captures34
- Readers34
- 34
Article Description
Attenuated Salmonella have been used as vectors to deliver foreign antigens as live vaccines. We have previously developed an efficient surface-display system by genetically engineering 987P fimbriae to present transmissible gastroenteritis virus (TGEV) C and A epitopes for the induction of anti-TGEV antibodies with a Salmonella vaccine vector. Here, this system was compared with an autotransporter protein surface display system. The TGEV C and A epitopes were fused to the passenger domain of the MisL autotransporter of Salmonella. Expression of both the MisL- and 987P subunit FasA-fusions to the TGEV epitopes were under the control of in vivo-induced promoters. Expression of the TGEV epitopes from the Salmonella typhimurium CS4552 ( crp cya asd pgtE ) vaccine strain was greater when the epitopes were fused to MisL than when they were fused to the 987P FasA subunit. However, when BALB/c mice were orally immunized with the Salmonella vector expressing the TGEV epitopes from either one of the fusion constructs or both together, the highest level of anti-TGEV antibody was obtained with the 987P-TGEV immunogen-displaying vector. This result suggested that better immune responses towards specific epitopes could be obtained by using a polymeric display system such as fimbriae.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0264410X06012011; http://dx.doi.org/10.1016/j.vaccine.2006.11.006; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33846239998&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/17169467; https://linkinghub.elsevier.com/retrieve/pii/S0264410X06012011; https://dx.doi.org/10.1016/j.vaccine.2006.11.006
Elsevier BV
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