A human monoclonal antibody to neutralize all four serotypes of dengue virus derived from patients at the convalescent phase of infection
Virology, ISSN: 0042-6822, Vol: 576, Page: 74-82
2022
- 3Citations
- 23Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations3
- Citation Indexes3
- CrossRef3
- Captures23
- Readers23
- 23
Article Description
Dengue virus (DENV) is a prevalent mosquito-transmitted human pathogen, causing about 100 million cases of acute dengue fever and 21,000 deaths annually worldwide. Therapeutic neutralizing antibodies against dengue virus might be effective to treat severe dengue fever. Here, we showed that human monoclonal antibody (HMAb) 9C7 bound to all four intact serotypes of DENV but not to the recombinant envelope protein, suggesting HMAb 9C7 recognized a conformational epitope of the envelope protein. Taken together our results suggested that HMAb 9C7 neutralized all four serotypes of DENV in vitro and, for DENV-1, indicated activity at the pre- and post-attachment steps in the viral life cycle. HMAb 9C7 potently protected suckling mice from lethal challenge with all four serotypes of DENV. FcγRII-mediated uptake of immune complexes and antibody-dependent enhancement at low doses of the antibody were abolished by two Leu-to-Ala (9C7-LALA) mutations or deletion of nine amino acids (9C7-9del) in HMAb 9C7 Fc. Therefore, HMAb 9C7 represented a promising prophylactic and therapeutic agent against all four serotypes of DENV.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S004268222200160X; http://dx.doi.org/10.1016/j.virol.2022.09.007; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85138772549&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36183498; https://linkinghub.elsevier.com/retrieve/pii/S004268222200160X; https://dx.doi.org/10.1016/j.virol.2022.09.007
Elsevier BV
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