Analysis of the relationship between replication of the Hokkaido genotype of Puumala orthohantavirus and autophagy
Virus Research, ISSN: 0168-1702, Vol: 318, Page: 198830
2022
- 7Captures
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Metrics Details
- Captures7
- Readers7
Article Description
Hantaviruses are potentially fatal zoonotic pathogens of the family Hantaviridae. No human infection by the Hokkaido genotype of Puumala orthohantavirus (PUUV-Hok) has been reported. However, other PUUV genotypes cause hemorrhagic fever with renal syndrome (HFRS) in humans. Autophagy is a highly conserved lysosomal degradation process in eukaryotic cells that affects the replication of various viruses. In this study, we examined the role of autophagy in PUUV-Hok replication. PUUV-Hok infection induced the expression of LC3-II, an autophagosome marker, and the nucleocapsid protein (NP) of PUUV-Hok was colocalized with punctate structures of LC3. Inhibition of autophagy using an siRNA for Atg5, an autophagy-related gene, increased the replication of PUUV-Hok, whereas an autophagy inducer decreased its replication. Inhibition of lysosomal degradation increased the expression of NP and LC3-II. In summary, autophagy was induced by PUUV-Hok infection, which inhibited PUUV-Hok replication in a manner related to the degradation of the NP in lysosomes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0168170222001587; http://dx.doi.org/10.1016/j.virusres.2022.198830; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85131522605&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35640779; https://linkinghub.elsevier.com/retrieve/pii/S0168170222001587; https://dx.doi.org/10.1016/j.virusres.2022.198830
Elsevier BV
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