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Anti-diabetic effects of GLP1 analogs are mediated by thermogenic interleukin-6 signaling in adipocytes

Cell Reports Medicine, ISSN: 2666-3791, Vol: 3, Issue: 11, Page: 100813
2022
  • 18
    Citations
  • 0
    Usage
  • 32
    Captures
  • 2
    Mentions
  • 10
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    18
  • Captures
    32
  • Mentions
    2
    • News Mentions
      2
      • News
        2
  • Social Media
    10
    • Shares, Likes & Comments
      10
      • Facebook
        10

Most Recent News

University of Texas Health Science Center Houston Details Findings in Interleukin-6 (Anti-diabetic Effects of Glp1 Analogs Are Mediated By Thermogenic Interleukin-6 Signaling In Adipocytes)

2023 JAN 20 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Diabetes Daily -- Data detailed on Intercellular Signaling Peptides and Proteins -

Article Description

Mechanisms underlying anti-diabetic effects of GLP1 analogs remain incompletely understood. We observed that in prediabetic humans exenatide treatment acutely induces interleukin-6 (IL-6) secretion by monocytes and IL-6 in systemic circulation. We hypothesized that GLP1 analogs signal through IL-6 in adipose tissue (AT) and used the mouse model to test if IL-6 receptor (IL-6R) signaling underlies the effects of the GLP1-IL-6 axis. We show that liraglutide transiently increases IL-6 in mouse circulation and IL-6R signaling in AT. Metronomic liraglutide treatment resulted in AT browning and thermogenesis linked with STAT3 activation. IL-6-blocking antibody treatment inhibited STAT3 activation in AT and suppressed liraglutide-induced increase in thermogenesis and glucose utilization. We show that adipose IL-6R knockout mice still display liraglutide-induced weight loss but lack thermogenic adipocyte browning and metabolism activation. We conclude that the anti-diabetic effects of GLP1 analogs are mediated by transient upregulation of IL-6, which activates canonical IL-6R signaling and thermogenesis.

Bibliographic Details

Gutierrez, Absalon D; Gao, Zhanguo; Hamidi, Vala; Zhu, Liang; Saint Andre, Karla Bermudez; Riggs, Kayla; Ruscheinsky, Monika; Wang, Hongyu; Yu, Yongmei; Miller, Charles; Vasquez, Hernan; Taegtmeyer, Heinrich; Kolonin, Mikhail G

Elsevier BV

Biochemistry, Genetics and Molecular Biology

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