Design of PLGA-Based Drug Delivery Systems Using a Physically-Based Sustained Release Model
Journal of Pharmaceutical Sciences, ISSN: 0022-3549, Vol: 111, Issue: 2, Page: 345-357
2022
- 6Citations
- 9Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations6
- Citation Indexes6
- CrossRef3
- Captures9
- Readers9
Article Description
An extensive data set has been developed and used to further the progress of a model-informed design of controlled drug release. An improved drug-release model with mechanistic modeling of hydrolytic polymer degradation is used and validated by comparing model predictions to in vitro experiments. Combining parameter estimates from the literature with model fits to the data set, this study can aid in achieving a priori design of controlled drug release from a model PLGA release system. A systematic series of model release systems were formulated with FITC-labeled dextran, as a surrogate for biopharmaceuticals, in PLGA rods over a broad range of compositions. While general comparisons between the model and experiments were favorable, important discrepancies were identified for several formulations with significant first-phase drug release. Supported by cross-sectional fluorescence microscopy images of the FITC-dextran distribution within the rods, this first-phase release was attributed to a combination of two main factors: (1) percolation of the drug particles and (2) swelling of and pore formation in the rods due to water uptake. These observations indicate the importance of careful selection of the PLGA polymer grade when designing drug release systems but also reflect a need for better understanding of phenomena such as pore formation. Adapting model parameters, without modifying the physical processes included in the model, enabled accurate fitting of the experimental data for all formulations, highlighting the applicability of the model.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0022354921004779; http://dx.doi.org/10.1016/j.xphs.2021.09.007; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85116814027&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34516986; https://linkinghub.elsevier.com/retrieve/pii/S0022354921004779; https://dx.doi.org/10.1016/j.xphs.2021.09.007
Elsevier BV
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