Clinical factors associated with late seizure remission after failed epilepsy surgery
Epilepsy & Behavior, ISSN: 1525-5050, Vol: 138, Page: 109055
2023
- 1Citations
- 13Captures
- 1Mentions
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Most Recent News
Reports from University of Washington Highlight Recent Findings in Seizures (Clinical Factors Associated With Late Seizure Remission After Failed Epilepsy Surgery)
2023 FEB 14 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Medical Devices Daily -- Researchers detail new data in Nervous System Diseases
Article Description
Some patients who initially fail epilepsy surgery later become seizure-free, but it is not clear how the clinical characteristics of the patients or post-operative modifications of anti-seizure medication (ASM) regimens contribute to late seizure remission. We performed a retrospective chart review of patients undergoing epilepsy surgery at the University of Washington Regional Epilepsy Center between 2007 and 2017, including patients receiving neocortical resection, temporal lobectomy, and hippocampal laser interstitial therapy (LITT) ablation. We assessed seizure freedom, ASM changes, seizure frequency at the first and last follow-up, and type of lesion. Two-tailed Fisher’s exact test and Mann-Whitney U test were used for statistical analyses. Two hundred and fifteen patients undergoing epilepsy surgery between 2007 and 2017 had both first and last follow-ups. Ninety-eight (46%) were not seizure-free at the first follow-up (mean 1.1 years post-operative). By the last follow-up (mean 4.7 years post-operative), 20% of those not initially seizure-free had become so. Those who were seizure-free at the last visit had lower median seizures per month in the first post-operative year (0.21 versus 0.95 per month in those not seizure-free, p < 0.001). There was also a significantly higher proportion of patients with cavernomas who were seizure-free at the last visit (25% vs. 1% of those not seizure-free at the last visit; p = 0.001), but no other differences in clinical characteristics. Of the 98 patients who had seizures at the first follow-up, 63% underwent post-operative modification of their ASM regimens. The rate of late seizure freedom was similar for patients with or without ASM changes: 21% were seizure-free at the last visit with ASM changes and 19% without ASM changes. There were no significant differences in which ASMs were changed between those who became seizure-free and those who did not, but patients who were subjected to further medical management were less likely to have had mesial temporal sclerosis (MTS) than those who were not. A number of patients not initially seizure-free who underwent ASM changes achieved seizure freedom as long as 10 years post-surgery. A substantial proportion of patients who initially fail epilepsy surgery will have late seizure remission. Those with cavernous hemangiomas were more likely to achieve late remission from seizures as were those with lower rates of seizures in the first year after surgery. The chances of achieving remission were similar in those with or without modification of their ASM regimens, but those with pre-operative MTS were more likely to achieve late seizure freedom without medication changes. At the individual level, patients may still achieve seizure freedom with ASM changes as long as ten years after the initial surgery.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1525505022005042; http://dx.doi.org/10.1016/j.yebeh.2022.109055; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85144395412&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36543042; https://linkinghub.elsevier.com/retrieve/pii/S1525505022005042; https://dx.doi.org/10.1016/j.yebeh.2022.109055
Elsevier BV
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