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Genome analysis of the mpox (formerly monkeypox) virus and characterization of core/variable regions

Genomics, ISSN: 0888-7543, Vol: 116, Issue: 1, Page: 110763
2024
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Article Description

Since smallpox was eradicated in 1980, the monkeypox virus (MPXV) has emerged as the most threatening orthopoxvirus in the world. In this study, we conducted a comprehensive analysis of the currently published complete genome sequences of the monkeypox virus. The core/variable regions were identified through core-pan analysis of MPXV. Besides single-nucleotide polymorphisms, our study also revealed that specific genes, multi-copy genes, repeat sequences, and recombination fragments are primarily distributed in the variable region. This result suggests that variable regions are not only more susceptible to single-base mutations, but also to events such as gene loss or gain, as well as recombination. Taken together, our results demonstrate the genomic characteristics of the core/variable regions of MPXV, and contribute to our understanding of the evolution of MPXV.

Bibliographic Details

Yu, Zehui; Zou, Xiaoxia; Deng, Zhaobin; Zhao, Mingde; Gu, Congwei; Fu, Lu; Xiao, Wudian; He, Manli; He, Lvqin; Yang, Qian; Liang, Sicheng; Wen, Chengli; Lü, Muhan

Elsevier BV

Biochemistry, Genetics and Molecular Biology

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