Genome analysis of the mpox (formerly monkeypox) virus and characterization of core/variable regions
Genomics, ISSN: 0888-7543, Vol: 116, Issue: 1, Page: 110763
2024
- 4Citations
- 16Captures
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Article Description
Since smallpox was eradicated in 1980, the monkeypox virus (MPXV) has emerged as the most threatening orthopoxvirus in the world. In this study, we conducted a comprehensive analysis of the currently published complete genome sequences of the monkeypox virus. The core/variable regions were identified through core-pan analysis of MPXV. Besides single-nucleotide polymorphisms, our study also revealed that specific genes, multi-copy genes, repeat sequences, and recombination fragments are primarily distributed in the variable region. This result suggests that variable regions are not only more susceptible to single-base mutations, but also to events such as gene loss or gain, as well as recombination. Taken together, our results demonstrate the genomic characteristics of the core/variable regions of MPXV, and contribute to our understanding of the evolution of MPXV.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0888754323002070; http://dx.doi.org/10.1016/j.ygeno.2023.110763; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85180572962&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38110129; https://linkinghub.elsevier.com/retrieve/pii/S0888754323002070; https://dx.doi.org/10.1016/j.ygeno.2023.110763
Elsevier BV
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