Optogenetic reprogramming of carbon metabolism using light-powering microbial proton pump systems
Metabolic Engineering, ISSN: 1096-7176, Vol: 72, Page: 227-236
2022
- 15Citations
- 25Captures
- 4Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations15
- Citation Indexes14
- 14
- CrossRef10
- Patent Family Citations1
- Patent Families1
- Captures25
- Readers25
- 25
- Mentions4
- News Mentions3
- News3
- Blog Mentions1
- Blog1
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Article Description
In microbial fermentative production, ATP regeneration, while crucial for cellular processes, conflicts with efficient target chemical production because ATP regeneration exhausts essential carbon sources also required for target chemical biosynthesis. To wrestle with this dilemma, we harnessed the power of microbial rhodopsins with light-driven proton pumping activity to supplement with ATP, thereby facilitating the bioproduction of various chemicals. We first demonstrated a photo-driven ATP supply and redistribution of metabolic carbon flows to target chemical synthesis by installing already-known delta rhodopsin (dR) in Escherichia coli. In addition, we identified novel rhodopsins with higher proton pumping activities than dR, and created an engineered cell for in vivo self-supply of the rhodopsin-activator, all- trans -retinal. Our concept exploiting the light-powering ATP supplier offers a potential increase in carbon use efficiency for microbial productions through metabolic reprogramming.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1096717622000489; http://dx.doi.org/10.1016/j.ymben.2022.03.012; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85127492753&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35346842; https://linkinghub.elsevier.com/retrieve/pii/S1096717622000489; https://dx.doi.org/10.1016/j.ymben.2022.03.012
Elsevier BV
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