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Acute leukemias in children with Down syndrome

Molecular Genetics and Metabolism, ISSN: 1096-7192, Vol: 107, Issue: 1, Page: 25-30
2012
  • 39
    Citations
  • 0
    Usage
  • 128
    Captures
  • 8
    Mentions
  • 3
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    39
  • Captures
    128
  • Mentions
    8
    • References
      8
      • Wikipedia
        8
  • Social Media
    3
    • Shares, Likes & Comments
      3
      • Facebook
        3

Review Description

Children with Down syndrome (DS) often present with hematopoietic abnormalities, and are at increased risk of developing leukemia. Specifically, 3–10% of newborns with DS are diagnosed with transient myeloproliferative disease, and children with DS are 500 times more likely to develop acute megakaryoblastic leukemia (AMKL) and 20 times more likely to develop acute lymphoblastic leukemia (ALL) than typical children. This review examines the characteristics of these leukemias and their development in the unique genetic background of trisomy 21. A discussion is also provided for areas of future research and potential therapeutic development.

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