Health assessment of gasoline and fuel oxygenate vapors: Reproductive toxicity assessment
Regulatory Toxicology and Pharmacology, ISSN: 0273-2300, Vol: 70, Issue: 2, Page: S48-S57
2014
- 22Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations22
- Citation Indexes19
- 19
- CrossRef11
- Policy Citations3
- Policy Citation3
- Captures24
- Readers24
- 24
Article Description
Vapor condensates of baseline gasoline (BGVC), or gasoline-blended with methyl tertiary butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA) were evaluated for reproductive toxicity in rats at target concentrations of 2000, 10,000, or 20,000 mg/m 3, 6 h/day, 7 days/week. BGVC and G/MTBE were assessed over two generations, the others for one generation. BGVC and G/MTBE F1 offspring were evaluated for neuropathology and changes in regional brain glial fibrillary acidic protein content. No neurotoxicity was observed. Male kidney weight was increased consistent with light hydrocarbon nephropathy. In adult rats, decreased body weight gain and increased liver weight were seen. Spleen weight decreased in adults and pups exposed to G/TBA. No pathological changes to reproductive organs occurred in any study. Decreased food consumption was seen in G/TAME lactating females. Transient decreases in G/TAME offspring weights were observed during lactation. Except for a minor increase in time to mating in G/TBA which did not affect other reproductive parameters, there were no adverse reproductive findings. The NOAEL for reproductive and offspring parameters was 20,000 mg/m 3 for all vapor condensates except for lower offspring NOAELs of 10,000 mg/m 3 for G/TBA and 2000 mg/m 3 for G/TAME.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0273230014000774; http://dx.doi.org/10.1016/j.yrtph.2014.04.014; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84908266594&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/24813181; https://linkinghub.elsevier.com/retrieve/pii/S0273230014000774
Elsevier BV
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