Successful treatment of ongoing intestinal allograft rejection permits recovery of graft structure and function
The American Journal of Surgery, ISSN: 0002-9610, Vol: 165, Issue: 1, Page: 131-136
1993
- 13Citations
- 1Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations13
- Citation Indexes13
- CrossRef13
- 11
- Captures1
- Readers1
Article Description
Acute rejection episodes often complicate clinical small bowel transplantation, which prompted us to investigate whether such episodes can be reversed and the intestinal graft salvaged. Inbred Lewis rats that received fully allogeneic Brown-Norway small bowel allografts were treated with cyclosporin A (10 mg/kg) for 5 days, and the drug was then discontinued. Clinical and histologic signs of acute rejection developed, and the animals were subsequently treated with FK 506 (2 mg/kg) on days 14, 16, and 18. Survival was significantly prolonged (201.7±46.8 days) when compared with animals that were not administered FK 506 (16.5±0.8 days) or allograft recipients that received no immunosuppressive therapy (10.8±0.7 days). The histologic changes and functional impairment due to rejection that were observed prior to the start of the FK 506-therapy were reversed. However, biopsy specimens of all animals exhibited features of chronic rejection. This study provides evidence that acute rejection of intestinal allografts can be successfully treated with a short course of FK 506.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0002961005804167; http://dx.doi.org/10.1016/s0002-9610(05)80416-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027381651&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7678188; https://linkinghub.elsevier.com/retrieve/pii/S0002961005804167; http://linkinghub.elsevier.com/retrieve/pii/S0002961005804167; http://api.elsevier.com/content/article/PII:S0002961005804167?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0002961005804167?httpAccept=text/plain; http://dx.doi.org/10.1016/s0002-9610%2805%2980416-7; https://dx.doi.org/10.1016/s0002-9610%2805%2980416-7
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