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Protective Role of TNF- α in Respiratory Syncytial Virus Infection In Vitro and In Vivo

The American Journal of the Medical Sciences, ISSN: 0002-9629, Vol: 311, Issue: 5, Page: 201-204
1996
  • 2
    Citations
  • 0
    Usage
  • 7
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    2
    • Citation Indexes
      2
      • CrossRef
        2
  • Captures
    7

Article Description

Respiratory syncytial virus (RSV) infection causes substantial morbidity in young children and immunocompromised adults, yet its pathogenesis is poorly understood. Because the proinflammatory cytokine tumor necrosis factoralpha (TNF- α ) may be important in host response to viral infection, HEp-2 cells were treated with TNF- α and mice were given TNF- α antibody before RSV infection. Pretreatment of HEp-2 cells with TNF- α inhibited RSV replication as determined by cytopathic effect. Respiratory syncytial virus-infected BALB/c mice treated with antibody to TNF- α had greater maximal weight loss and slower recovery time than control mice. These results suggest a protective role for TNF- α in RSV infection.

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