In vivo hemodynamic, histologic, and antimineralization characteristics of the Mosaic bioprosthesis
The Annals of Thoracic Surgery, ISSN: 0003-4975, Vol: 71, Issue: 1, Page: 92-99
2001
- 35Citations
- 16Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations35
- Citation Indexes35
- 35
- CrossRef21
- Captures16
- Readers16
- 16
Article Description
Background. Performance of bioprosthetic valves is limited by tissue degeneration due to calcification with reduced performance and longevity. The Mosaic bioprosthetic valve (Medtronic Heart Valves, Inc, Minneapolis, MN) combines zero pressure fixation, antimineralization properties of α-amino oleic acid (AOA), and a proven stent design. We tested the hypothesis that AOA treatment of Mosaic valves improves hemodynamics, antimineralization properties, and survival in a chronic ovine model. Methods. Mitral valves were implanted in juvenile sheep with Mosaic valves with AOA treatment (n = 8) or without AOA treatment (non-AOA, n = 8), or Hancock I (HAN, n = 4) tissue valves, and explanted at 20 postoperative weeks. Results. Survival was equivalent in AOA and non-AOA (140 ± 0.4 and 129 ± 30 days), but was significantly less in HAN (82 ± 35). Leaflet calcium (μgCa/mg tissue) was less in AOA (9.6 ± 13.9; p < 0.05 versus non-AOA and HAN) than non-AOA (96.3 ± 63.8) and HAN (130.8 ± 43.2). Explant valve orifice area (cm 2 ) was significantly preserved in the AOA group compared with the non-AOA group (1.5 ± 0.7 vs 0.8 ± 0.3; p < 0.05 versus non-AOA and HAN). Conclusions. We conclude that AOA treatment of Mosaic valves reduces leaflet calcification and valve gradient in juvenile sheep, and that the Mosaic design and fixation features may offer survival advantages that must be confirmed in extended trials.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0003497500019895; http://dx.doi.org/10.1016/s0003-4975(00)01989-5; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035136076&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11216817; http://linkinghub.elsevier.com/retrieve/pii/S0003497500019895; http://api.elsevier.com/content/article/PII:S0003497500019895?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0003497500019895?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0003497500019895; http://dx.doi.org/10.1016/s0003-4975%2800%2901989-5; https://dx.doi.org/10.1016/s0003-4975%2800%2901989-5
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know