Contributions of bronchoscopic microsampling in the supplemental diagnosis of small peripheral lung carcinoma
The Annals of Thoracic Surgery, ISSN: 0003-4975, Vol: 76, Issue: 5, Page: 1668-1672
2003
- 27Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations27
- Citation Indexes27
- 27
- CrossRef21
- Captures12
- Readers12
- 12
Article Description
Making a preoperative pathologic diagnosis in patients with small lung nodules remains challenging. We have developed a new, noninvasive bronchoscopic microsampling probe to examine biochemical substances in epithelial lining fluid. We used this probe to measure tumor markers in fluid from tissues surrounding lung nodules less than 30 mm in diameter to test its adjunctive diagnostic utility in lung cancer. In 12 patients, epithelial lining fluid was collected in triplicate or duplicate from tissue within 2 cm of small peripheral lung nodules and from the contralateral lung. The diagnosis of adenocarcinoma was surgically confirmed in all patients. Fifteen patients without lung cancer served as controls. Concentrations of carcinoembryonic antigen, cytokeratin fragment 19, and sialyl SSEA-1 were measured in the fluid. Carcinoembryonic antigen and cytokeratin fragment 19 concentrations were significantly higher in fluid near the nodules (median, 8.7 and 87.2 ng/mg, respectively) than on the contralateral sides (median, 1.5 and 3.7 ng/mg, respectively) or in fluid collected from the controls (median, 2.0 and 2.8 ng/mg, respectively). Measurements of carcinoembryonic antigen and cytokeratin fragment 19 collected by our microsampling probe may be a useful diagnostic adjunct in patients with small peripheral lung nodules.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0003497503010154; http://dx.doi.org/10.1016/s0003-4975(03)01015-4; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0242721206&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/14602308; http://linkinghub.elsevier.com/retrieve/pii/S0003497503010154; http://api.elsevier.com/content/article/PII:S0003497503010154?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0003497503010154?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0003497503010154; http://dx.doi.org/10.1016/s0003-4975%2803%2901015-4; https://dx.doi.org/10.1016/s0003-4975%2803%2901015-4
Elsevier BV
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