Role of mitochondria in oxidative stress and ageing
Biochimica et Biophysica Acta (BBA) - Bioenergetics, ISSN: 0005-2728, Vol: 1366, Issue: 1, Page: 53-67
1998
- 588Citations
- 233Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations588
- Citation Indexes588
- 588
- CrossRef421
- Captures233
- Readers233
- 233
Article Description
Mitochondria are deeply involved in the production of reactive oxygen species through one-electron carriers in the respiratory chain; mitochondrial structures are also very susceptible to oxidative stress as evidenced by massive information on lipid peroxidation, protein oxidation, and mitochondrial DNA (mtDNA) mutations. Oxidative stress can induce apoptotic death, and mitochondria have a central role in this and other types of apoptosis, since cytochrome c release in the cytoplasm and opening of the permeability transition pore are important events in the apoptotic cascade. The discovery that mtDNA mutations are at the basis of a number of human pathologies has profound implications: maternal inheritance of mtDNA is the basis of hereditary mitochondrial cytopathies; accumulation of somatic mutations of mtDNA with age has represented the basis of the mitochondrial theory of ageing, by which a vicious circle is established of mtDNA damage, altered oxidative phosphorylation and overproduction of reactive oxygen species. Experimental evidence of respiratory chain defects and of accumulation of multiple mtDNA deletions with ageing is in accordance with the mitochondrial theory, although some other experimental findings are not directly ascribable to its postulates.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0005272898001200; http://dx.doi.org/10.1016/s0005-2728(98)00120-0; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032504657&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9714734; http://linkinghub.elsevier.com/retrieve/pii/S0005272898001200; http://api.elsevier.com/content/article/PII:S0005272898001200?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0005272898001200?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0005272898001200; http://dx.doi.org/10.1016/s0005-2728%2898%2900120-0; https://dx.doi.org/10.1016/s0005-2728%2898%2900120-0
Elsevier BV
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