Synergistic permeability enhancing effect of lysophospholipids and fatty acids on lipid membranes
Biochimica et Biophysica Acta (BBA) - Biomembranes, ISSN: 0005-2736, Vol: 1564, Issue: 1, Page: 256-262
2002
- 73Citations
- 52Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations73
- Citation Indexes73
- 73
- CrossRef55
- Captures52
- Readers52
- 52
Article Description
The permeability-enhancing effects of the two surfactants, 1-palmitoyl-2-lyso- sn -gycero-3-phosphocholine (lysoPPC) and palmitic acid (PA), on lipid membranes that at physiological temperatures are in the gel, fluid, and liquid-ordered phases were determined using the concentration-dependent self-quenching properties of the hydrophilic marker, calcein. Adding lysoPPC to lipid membranes in the gel-phase induced a time-dependent calcein release curve that can be described by the sum of two exponentials, whereas PA induces a considerably more complex release curve. However, when lysoPPC and PA were added simultaneously in equimolar concentrations, a dramatic synergistic permeability-enhancing effect was observed. In contrast, when both lysoPPC and PA are added to liposomal membranes that are in the fluid or liquid-ordered phases, no effect on the transmembrane permeation of calcein was observed.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0005273602004613; http://dx.doi.org/10.1016/s0005-2736(02)00461-3; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037136068&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12101020; http://linkinghub.elsevier.com/retrieve/pii/S0005273602004613; http://api.elsevier.com/content/article/PII:S0005273602004613?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0005273602004613?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0005273602004613; http://dx.doi.org/10.1016/s0005-2736%2802%2900461-3; https://dx.doi.org/10.1016/s0005-2736%2802%2900461-3
Elsevier BV
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