Cyclic AMP decseases LDL catabolism and cholesterol synthesis in the human hepatoma cell line HepG2
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 156, Issue: 1, Page: 424-431
1988
- 13Citations
- 1Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef12
- Captures1
- Readers1
Article Description
A 24h pretreatment of the human hepatoma cell line HepG2 with dibutyryl cyclic AMP in the presence of theophylline induced a dose dependent decrease in low density lipoprotein binding, uptake and degradation. This effect is most likely due to a reduction of the LDL receptor number. Sterol synthesis from sodium acetate is markedly inhibited, either in the presence or absence of LDL, whereas synthesis from mevalonic acid is unchanged. Cyclic AMP also induced a decrease in hydroxy methyl glutaryl coenzyme A reductase activity. These effects of cyclic AMP might be involved in some hormonal regulation of the LDL pathway and cholesterol metabolism in the liver.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006291X88808581; http://dx.doi.org/10.1016/s0006-291x(88)80858-1; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023814553&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2845980; https://linkinghub.elsevier.com/retrieve/pii/S0006291X88808581; http://linkinghub.elsevier.com/retrieve/pii/S0006291X88808581; http://api.elsevier.com/content/article/PII:S0006291X88808581?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0006291X88808581?httpAccept=text/plain; http://dx.doi.org/10.1016/s0006-291x%2888%2980858-1; https://dx.doi.org/10.1016/s0006-291x%2888%2980858-1
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