Calcium rise in cultured neurons from medial septum elicits calcium waves in surrounding glial cells
Brain Research, ISSN: 0006-8993, Vol: 957, Issue: 2, Page: 287-297
2002
- 6Citations
- 26Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations6
- Citation Indexes6
- CrossRef6
- Captures26
- Readers26
- 26
Article Description
One prerequisite for understanding the physiological relevance of intercellular calcium waves in glia is the examination of mechanisms that trigger these waves. Here, we show that stimulation of cultured septal neurons to produce a large and sustained calcium rise in the soma can initiate calcium waves in surrounding glial cells. The initiation of calcium waves is dependent on calcium influx through voltage-gated calcium channels on the neuron. The waves are not due to direct stimulation of the glial cells or to loss of neuronal membrane integrity. Mechanism of wave initiation is distinct from that involved in wave propagation and does not involve glutamate or acetylcholine release. Communication via gap junctions, or nitric oxide production, is not involved in the initial signaling between a stimulated neuron and the surrounding astrocytes. Suramin, a blocker of P2 receptors blocked the waves but failed to abolish the responses in glial cells immediately surrounding the stimulated neuron. Our results suggest that patterns of calcium rises on neurons, like those seen in glutamate cytotoxicity, can cause calcium waves in surrounding glial cells.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006899302036181; http://dx.doi.org/10.1016/s0006-8993(02)03618-1; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037073552&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12445971; http://linkinghub.elsevier.com/retrieve/pii/S0006899302036181; http://api.elsevier.com/content/article/PII:S0006899302036181?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0006899302036181?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0006899302036181; http://dx.doi.org/10.1016/s0006-8993%2802%2903618-1; https://dx.doi.org/10.1016/s0006-8993%2802%2903618-1
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know