Protein extravasation and cellular uptake after high-dose human-albumin treatment of transient focal cerebral ischemia in rats
Brain Research, ISSN: 0006-8993, Vol: 827, Issue: 1, Page: 237-242
1999
- 43Citations
- 10Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations43
- Citation Indexes43
- 43
- CrossRef37
- Captures10
- Readers10
- 10
Article Description
Treatment with human albumin administered intravenously in the immediate post-ischemic period following a 2-h period of transient focal cerebral ischemia leads to a reduction of cortical infarction in rat. Immunohistochemistry with antibodies to rat immunoglobulins (IgG), rat albumin and (exogenous) human albumin was used to study blood–brain barrier changes. The degree of IgG extravasation was not changed by human-albumin treatment. Diffuse signals and uptake into necrotic neurons was seen in cortex of saline animals. In animals treated with human albumin, cortical neurons with preserved structural features had taken up human albumin. Treatment with human albumin may provide direct neuronal protection.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006899399013049; http://dx.doi.org/10.1016/s0006-8993(99)01304-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033535805&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/10320717; http://linkinghub.elsevier.com/retrieve/pii/S0006899399013049; http://api.elsevier.com/content/article/PII:S0006899399013049?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0006899399013049?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0006899399013049; http://dx.doi.org/10.1016/s0006-8993%2899%2901304-9; https://dx.doi.org/10.1016/s0006-8993%2899%2901304-9
Elsevier BV
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