Coinhibition of viral interferon induction by benzo[ a ]pyrene in association with occupation-related particles
Environmental Research, ISSN: 0013-9351, Vol: 52, Issue: 1, Page: 83-98
1990
- 3Citations
- 15Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Benzo[ a ]pyrene (B[ a ]P) in combination with coal, asbestos, silicate, or metal particles was studied for its inhibitory effects on interferon-α/β induction by influenza virus in rhesus monkey kidney (LLC-MK 2 ) cell monolayers. B[ a ]P per se had no adverse effect on the induction process. However, when cell cultures were pretreated with B[ a ]P that was bioactivated by rat liver S9 homogenate, from 52 to 65% inhibition of interferon induction occurred. Significantly greater ( P < 0.05) depression (coinhibition) of viral interferon induction (>83%) resulted when bioactivated B[ a ]P was incorporated with coal particles representative of coal rank (anthracite, bituminous, lignite, peat). Coinhibition affected by bioactivated B[ a ]P was coal rank-independent but any interferon inhibitory activity affected by coal particles per se was coal rank-dependent. When metals (aluminum, aluminum oxide, ferric oxide, nickel, or chromium) or asbestos fibers (chrysotile, crocidolite, anthophyllite, or amosite) were individually mixed with bioactivated B[ a ]P, coinhibition of cellular interferon synthesis also resulted which was significantly greater ( P < 0.05) than that manifested by bioactivated B[ a ]P or particles per se. Coinhibition of interferon induction by silicates (Min-U-Sil, DQ-12, hypersthene, or wollastonite) and the bioactivated hydrocarbon was not in evidence although some silicates alone partially inhibited the induction process. Viral interferon induction was inhibited in a dose-response manner by B[ a ]P (±S9) in combination with selected particles. The adsorption of B[ a ]P to all types of particles was no more than 5.98 μg B[ a ]P/mg of particles and, moreover, less than 0.5% by weight. These findings provide further evidence that bioactivated B[ a ]P and occupation-related particles act together to coinhibit a biological defense mechanism, the interferon induction phase of the interferon system.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0013935105801537; http://dx.doi.org/10.1016/s0013-9351(05)80153-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0025084048&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2351130; http://linkinghub.elsevier.com/retrieve/pii/S0013935105801537; http://api.elsevier.com/content/article/PII:S0013935105801537?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0013935105801537?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0013935105801537; http://dx.doi.org/10.1016/s0013-9351%2805%2980153-7; https://dx.doi.org/10.1016/s0013-9351%2805%2980153-7
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know