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Coinhibition of viral interferon induction by benzo[ a ]pyrene in association with occupation-related particles

Environmental Research, ISSN: 0013-9351, Vol: 52, Issue: 1, Page: 83-98
1990
  • 3
    Citations
  • 0
    Usage
  • 15
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    3
    • Citation Indexes
      2
    • Policy Citations
      1
      • Policy Citation
        1
  • Captures
    15

Article Description

Benzo[ a ]pyrene (B[ a ]P) in combination with coal, asbestos, silicate, or metal particles was studied for its inhibitory effects on interferon-α/β induction by influenza virus in rhesus monkey kidney (LLC-MK 2 ) cell monolayers. B[ a ]P per se had no adverse effect on the induction process. However, when cell cultures were pretreated with B[ a ]P that was bioactivated by rat liver S9 homogenate, from 52 to 65% inhibition of interferon induction occurred. Significantly greater ( P < 0.05) depression (coinhibition) of viral interferon induction (>83%) resulted when bioactivated B[ a ]P was incorporated with coal particles representative of coal rank (anthracite, bituminous, lignite, peat). Coinhibition affected by bioactivated B[ a ]P was coal rank-independent but any interferon inhibitory activity affected by coal particles per se was coal rank-dependent. When metals (aluminum, aluminum oxide, ferric oxide, nickel, or chromium) or asbestos fibers (chrysotile, crocidolite, anthophyllite, or amosite) were individually mixed with bioactivated B[ a ]P, coinhibition of cellular interferon synthesis also resulted which was significantly greater ( P < 0.05) than that manifested by bioactivated B[ a ]P or particles per se. Coinhibition of interferon induction by silicates (Min-U-Sil, DQ-12, hypersthene, or wollastonite) and the bioactivated hydrocarbon was not in evidence although some silicates alone partially inhibited the induction process. Viral interferon induction was inhibited in a dose-response manner by B[ a ]P (±S9) in combination with selected particles. The adsorption of B[ a ]P to all types of particles was no more than 5.98 μg B[ a ]P/mg of particles and, moreover, less than 0.5% by weight. These findings provide further evidence that bioactivated B[ a ]P and occupation-related particles act together to coinhibit a biological defense mechanism, the interferon induction phase of the interferon system.

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