Biochemical effects of DDT and DDE in rat and mouse liver
Environmental Research, ISSN: 0013-9351, Vol: 46, Issue: 1, Page: 39-47
1988
- 8Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations8
- Citation Indexes7
- CrossRef6
- Policy Citations1
- 1
- Captures4
- Readers4
Article Description
The effects of two hepatocarcinogens, 1,1,1-trichloro-2,2-di-4-(chlorophenyl)ethane and 1,1-dichloro-2,2-bis( p -chlorophenyl)ethylene (DDT and DDE), on hepatic biochemical parameters were examined in adult female rats and mice. Two oral administrations of DDT (66 mg/kg) at 21 and 4 hr before sacrifice increased rat hepatic microsomal cytochrome P -450 content by 28%. After two oral treatments with 175 and 525 mg/kg of DDE, rat hepatic ornithine decarboxylase (ODC) activity was increased 6.5- and 22-fold while cytochrome P -450 content was elevated by 58 and 123%, respectively. As DDT did not actuely increase rat ODC activity, a chronic exposure to DDT was also performed. Thirty days after a single oral treatment with 90 mg/kg DDT, rat hepatic ODC activity was not elevated above control values. Neither DDT nor DDE caused any significant biochemical changes in mouse liver. Thus rat hepatic ODC, a biochemical marker for tumor-promoters, responded to DDE, the stronger of the two hepatocarcinogens, but not to DDT. Neither DDT nor DDE caused hepatic DNA damage in either rat or mouse liver.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0013935188800574; http://dx.doi.org/10.1016/s0013-9351(88)80057-4; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023945348&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/3371291; http://linkinghub.elsevier.com/retrieve/pii/S0013935188800574; http://api.elsevier.com/content/article/PII:S0013935188800574?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0013935188800574?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0013935188800574; http://dx.doi.org/10.1016/s0013-9351%2888%2980057-4; https://dx.doi.org/10.1016/s0013-9351%2888%2980057-4
Elsevier BV
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