Genotype distribution of estrogen receptor-α gene polymorphisms in italian women with surgical uterine leiomyomas
Fertility and Sterility, ISSN: 0015-0282, Vol: 75, Issue: 3, Page: 567-570
2001
- 39Citations
- 10Captures
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Metrics Details
- Citations39
- Citation Indexes39
- 39
- CrossRef29
- Captures10
- Readers10
Article Description
Objective: To explore a possible association between estrogen receptor-α (ER-α) gene polymorphisms and development of uterine leiomyomas. Design: Case–control study. Setting: University teaching hospital. Patient(s): 119 women with clinically and surgically diagnosed uterine leiomyomas. Intervention(s): Therapeutic hysterectomy. Main Outcome Measure(s): Frequency and distribution of ER-α gene polymorphisms. Result(s): No statistically significant differences between controls and patients in the allele frequency and genotype distribution were found when Pvu II and Xba I restriction polymorphism sites were analyzed separately. When the two ER-α gene polymorphisms were analyzed in combination, five major genotypes were recognized in controls or patients; the frequency differed slightly but not significantly between groups. Conclusion(s): The Pvu II and Xba I polymorphisms in the ER-α gene do not produce different risks of developing uterine leiomyomas.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S001502820001760X; http://dx.doi.org/10.1016/s0015-0282(00)01760-x; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035116677&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/11239543; https://linkinghub.elsevier.com/retrieve/pii/S001502820001760X; http://linkinghub.elsevier.com/retrieve/pii/S001502820001760X; http://api.elsevier.com/content/article/PII:S001502820001760X?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S001502820001760X?httpAccept=text/plain; http://dx.doi.org/10.1016/s0015-0282%2800%2901760-x; https://dx.doi.org/10.1016/s0015-0282%2800%2901760-x
Elsevier BV
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