Comparison of the Effects of Various Inducers on 7-Alkoxycoumarin O-Dealkylase Activities in Liver Microsomes
Japanese Journal of Pharmacology, ISSN: 0021-5198, Vol: 50, Issue: 1, Page: 1-9
1989
- 2Citations
- 2Captures
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Article Description
The effects of six inducers and malotilate on 7-alkoxycoumarin O-dealkylase activities in rat liver microsomes were examined. Phenobarbital (PB) (100 mg/kg) was administered intraperitoneally to rats for 6 days; 3-methylcholan-threne (3-MC) (40 mg/kg), β -naphthoflavone ( β -NF) (40 mg/kg), isosafrole (150 mg/kg) and polychlorinated biphenyls (PCB) (100 mg/kg) were administered intraperitoneally for 3 days; isoniazid (INH) (50 mg/kg) was administered intraperitoneally for 10 days; and malotilate (500 mg/kg) was administered orally for 3 days. The O-dealkylase activities toward 7-methoxycoumarin (7-MC), 7-ethoxycoumarin (7-EC) and 7-propoxycoumarin (7-PC) were examined 24 hr after the final administration of the drugs. The ratios of 7-EC O-deethylase and 7-PC O-depropylase to 7-MC O-demethylase activity in the control and six inducer-treated groups were compared. The ratios in the groups treated with the six compounds, each of which induces a different form(s) of cytochrome P-450 (P-450), were clearly different from each other. Therefore, the measurement of 7-alkoxycoumarin O-dealkylase activities should be extremely useful for the routine determination of the molecular species of P-450. On the other hand, the ratio in the malotilate-treated group was different from that in any other inducer-treated group, so that there might be a possibility that malotilate induced a form(s) of P-450 that is different from any of the already known species.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021519819424797; http://dx.doi.org/10.1016/s0021-5198(19)42479-7; https://linkinghub.elsevier.com/retrieve/pii/S0021519819424797; https://api.elsevier.com/content/article/PII:S0021519819424797?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:S0021519819424797?httpAccept=text/plain; https://dul.usage.elsevier.com/doi/; http://dx.doi.org/10.1016/s0021-5198%2819%2942479-7; https://dx.doi.org/10.1016/s0021-5198%2819%2942479-7
Elsevier BV
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