Inhibition of smooth muscle cell migration by the p21 cyclin-dependent kinase inhibitor (Cip1)
Atherosclerosis, ISSN: 0021-9150, Vol: 132, Issue: 1, Page: 53-59
1997
- 40Citations
- 3Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations40
- Citation Indexes40
- 40
- CrossRef32
- Captures3
- Readers3
Article Description
In vascular smooth muscle cells (SMCs), proliferation and migration contribute to lesion formation after arterial injury. In the cell cycle, several cyclin-dependent kinases (cdks) inhibitors are implicated in the regulating of cyclin–cdk activity such as p21 Cip1, p16 Ink4 and p27 Kip1. Although Cip1 inhibits SMC proliferation, its effects on SMC migration are unknown. To test the hypothesis that Cip1 inhibits SMCs migration and proliferation, we transfected the Cip1 gene into a strain of rabbit aortic SMCs (SM3 cells). Both the spreading and the attachment of Cip1-transfected SM3 cells to extracellular matrices (ECMs) were inhibited compared to that of vector-transfected cells. In the modified Boyden's chamber assay the effect of fibronectin on the migratory activity of Cip1-transfected SM3 cells was significantly less than that of vector transfected cells in response to PDGF-BB. These data suggested that Cip1 inhibited both the migration and proliferation of SMC.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0021915097000865; http://dx.doi.org/10.1016/s0021-9150(97)00086-5; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030787332&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9247359; https://linkinghub.elsevier.com/retrieve/pii/S0021915097000865; http://linkinghub.elsevier.com/retrieve/pii/S0021915097000865; http://api.elsevier.com/content/article/PII:S0021915097000865?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0021915097000865?httpAccept=text/plain; http://dx.doi.org/10.1016/s0021-9150%2897%2900086-5; https://dx.doi.org/10.1016/s0021-9150%2897%2900086-5
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know