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A model for the regulation of growth in mammalian cells

Journal of Theoretical Biology, ISSN: 0022-5193, Vol: 55, Issue: 2, Page: 533-545
1975
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Article Description

A dynamic model of cellular growth is presented which allows accurate prediction of the growth kinetics of both growing and resting mammalian cells (mouse fibroblasts), provided that it is supplied with the information on the values of the relevant cellular parameters. The relative rates of protein and of ribosomal RNA syntheses calculated from the model agree quite well with those experimentally determined in growing and resting fibroblasts.

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