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Inhibition of tumor necrosis factor-α production by SK&F 98625, a CoA-independent transacylase inhibitor, in cultured rat peritoneal macrophages

Life Sciences, ISSN: 0024-3205, Vol: 62, Issue: 20, Page: PL297-PL302
1998
  • 11
    Citations
  • 0
    Usage
  • 3
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    11
    • Citation Indexes
      11
  • Captures
    3

Article Description

When rat peritoneal macrophages were incubated in medium containing thapsigargin, tumor necrosis factor-α (TNF-α) production was increased time-dependently. In the presence of SK&F 98625, a CoA-independent transacylase inhibitor, the thapsigargin-induced TNF-α production was inhibited dose-dependently. Platelet-activating factor (PAF) and prostaglandin E2 (PGE2) production were also inhibited by SK&F 98625. The SK&F 98625-induced inhibition of TNF-α production was not prevented by addition of PGE2. PAF antagonists such as E6123, L-652,731 and CV-6209 partially inhibited the thapsigargin-induced TNF-α production, suggesting that concurrently produced PAF in thapsigargin-stimulated macrophages up-regulates TNF-α production. The inhibition by SK&F 98625 of thapsigargin-induced TNF-α production might be partly due to the inhibition of PAF production.

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