Inhibition of tumor necrosis factor-α production by SK&F 98625, a CoA-independent transacylase inhibitor, in cultured rat peritoneal macrophages
Life Sciences, ISSN: 0024-3205, Vol: 62, Issue: 20, Page: PL297-PL302
1998
- 11Citations
- 3Captures
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Article Description
When rat peritoneal macrophages were incubated in medium containing thapsigargin, tumor necrosis factor-α (TNF-α) production was increased time-dependently. In the presence of SK&F 98625, a CoA-independent transacylase inhibitor, the thapsigargin-induced TNF-α production was inhibited dose-dependently. Platelet-activating factor (PAF) and prostaglandin E2 (PGE2) production were also inhibited by SK&F 98625. The SK&F 98625-induced inhibition of TNF-α production was not prevented by addition of PGE2. PAF antagonists such as E6123, L-652,731 and CV-6209 partially inhibited the thapsigargin-induced TNF-α production, suggesting that concurrently produced PAF in thapsigargin-stimulated macrophages up-regulates TNF-α production. The inhibition by SK&F 98625 of thapsigargin-induced TNF-α production might be partly due to the inhibition of PAF production.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0024320598001568; http://dx.doi.org/10.1016/s0024-3205(98)00156-8; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=17144458152&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9600332; https://linkinghub.elsevier.com/retrieve/pii/S0024320598001568; http://linkinghub.elsevier.com/retrieve/pii/S0024320598001568; http://api.elsevier.com/content/article/PII:S0024320598001568?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0024320598001568?httpAccept=text/plain; http://dx.doi.org/10.1016/s0024-3205%2898%2900156-8; https://dx.doi.org/10.1016/s0024-3205%2898%2900156-8
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