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Effect of intestinal helminthiasis on intestinal permeability of early primary schoolchildren

Transactions of the Royal Society of Tropical Medicine and Hygiene, ISSN: 0035-9203, Vol: 90, Issue: 6, Page: 666-669
1996
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Article Description

Intestinal permeability of 246 early primary schoolchildren at 2 schools (106 of whom were infected with intestinal helminths) was assessed by using the lactulose/mannitol differential absorption test. The ratio of the urinary recoveries of lactulose and mannitol was determined after oral administration of a standard solution of the 2 sugars. Assessment of intestinal permeability was repeated on 100 infected children after treatment and on a cohort of 68 uninfected children. Infected and uninfected groups were compared with respect to baseline lactulose/mannitol ratio ( LM1 ) and change in lactulose/mannitol ratio between assessments ( ΔLM ). The correlations between baseline intensity of infection and LM1, and between fall in intensity and ΔLM, were evaluated. Based on a crude index of socioeconomic status, each child was assigned to one of 3 socioeconomic groups; all but 3 children belonged to either groups 2 or 3. Trichuris trichiura and Ascaris lumbricoides were the 2 predominant infections; the hookworm infection rate was relatively low. The results suggested that helminthiasis exerted only a marginal effect on intestinal permeability, the impact of which in children from lower socioeconomic backgrounds was negligible in comparison with the cumulative effects of other factors.

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