Estramustine induces disorganization of microtubules, perinuclear retraction of vimentin and endoplasmatic reticulum, and inhibits cell migration
Acta Histochemica, ISSN: 0065-1281, Vol: 95, Issue: 2, Page: 155-167
1993
- 3Citations
- 2Captures
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Metrics Details
- Citations3
- Citation Indexes3
- CrossRef1
- Captures2
- Readers2
Article Description
The effects of the mitotic inhibitor estramustine on the cytoskeleton of DU 145 and AG 1518 cells were studied. Estramustine caused a partial disassembly of microtubules and withdrawal of microtubules from the cell periphery, disorganized microtubules and delayed regrowth of disassembled microtubules. It also induced a spheroid cellular morphology and affected cellular adhesion and survival. Sometimes microtubules seemed to be organized from several microtubule-organizing centers. The cytoskeleton-dependent cell migration was inhibited in the presence of estramustine and the microtubule-interacting vimentin and endoplasmatic reticulum retracted to the perinuclear area. Our results show that not only a complete disassembly of microtubules, but also disturbances of the microtubule network can have dramatic effects on microtubule-dependent processes and localization of cellular organelles. These effects could be of importance in the treatment of orostatic carcinoma with estramustine.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0065128111802540; http://dx.doi.org/10.1016/s0065-1281(11)80254-0; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027761887&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8135088; http://linkinghub.elsevier.com/retrieve/pii/S0065128111802540; http://api.elsevier.com/content/article/PII:S0065128111802540?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0065128111802540?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0065128111802540; http://dx.doi.org/10.1016/s0065-1281%2811%2980254-0; https://dx.doi.org/10.1016/s0065-1281%2811%2980254-0
Elsevier BV
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