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chapter 6 Nerve Growth Factors and Control of Nerve Growth

Current Topics in Developmental Biology, ISSN: 0070-2153, Vol: 16, Issue: C, Page: 207-252
1980
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Article Description

This chapter surveys developmental observations indicating the occurrence of target derived signals that permit a neuron to survive at and beyond a critical time in its life course. It introduces and illustrates the concepts of a trophic drive responsible for both survival and growth supportive production, and of specifying influences that signal the cell to proceed (or do away) with selected performances. With that conceptual background, the chapter examines, in detail, two examples of factors directed toward neurons. The first is a group of target-derived agents recently shown to promote survival and/or neurite growth in cultured ciliary neurons. The second is the classic nerve growth factor, including the mechanisms through which it may exercise its trophic functions of sensory and sympathetic neurons. The chapter also explores some signals and mechanisms for neurite growth. It discusses whether the concepts regarding the regulation of older cells apply during earlier phases of their life, before they connect with their target or even acquire a postmitotic neuronal identity.

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