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GnRH, brain mast cells and behavior

Progress in Brain Research, ISSN: 0079-6123, Vol: 141, Page: 315-325
2002
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Article Description

Mast cells, potent unicellular migratory glands, are found in all tissues and organs of the body including the brain and reproductive tract. GnRH is found in mast cell granules. This chapter presents evidence that the brain mast cell population increases under specific behavioral and endocrine states, including those associated with reproduction. Where pertinent, other mast cell-neuroendocrine interactions are also discussed. Mast cells are derived from the hematopoietic stem cell of the bone marrow. They circulate as committed precursors and undergo their final phenotypic differentiation in a tissue-specific manner. Progenitors of mast cells contain cytoplasmic granules and express RNAs encoding mast cell-associated proteases but lack expression of the high-affinity immunoglobulin E receptor. Mast cells are highly plastic in the sense that they can change phenotype when transplanted from one environment to another. Depending on their place of residence, alterations in environmental signals, and activational state, mast cells store or produce upon activation a wide range of mediators. Mast cells are long-lived cells and can undergo many rounds of activation, involving degranulation and replenishment.

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