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Chapter 3 Nerve growth factor and neuronal gene expression

Progress in Brain Research, ISSN: 0079-6123, Vol: 103, Issue: C, Page: 23-33
1994
  • 10
    Citations
  • 0
    Usage
  • 5
    Captures
  • 0
    Mentions
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    10
    • Citation Indexes
      10
  • Captures
    5

Article Description

This chapter reviews the studies examining the mechanisms whereby NGF (nerve growth factor) regulates gene expression in developing and mature sympathetic neurons. These studies demonstrate that NGF specifically up-regulates the expression of a subset of genes important to the growth and differentiation of neonatal sympathetic neurons, including those encoding the p75 NGF receptor, Tα1 α-tubulin, and tyrosine hydroxylase. These increases are independent of neuronal survival, and occur in a graded fashion at concentrations of NGF that preclude simple models based upon activation of the trkA NGF receptor alone. Furthermore, the magnitude of the increases in gene expression is a function of the spatial location of the increased NGF, with NGF exposure on distal axons eliciting less of an increase than NGF exposure on cell bodies. These studies also indicate that such NGF-induced changes in gene expression are not limited to developing neurons; increased NGF derived from the terminals of mature sympathetic neurons in vivo distally increases synthesis of the p75 NGF receptor relative to the trkA receptor, leading to an increased density of p75 NGF receptors on terminal neurites.

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