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Cross-reactivity of ten anti-prostate-specific antigen monoclonal antibodies with human glandular kallikrein

Urology, ISSN: 0090-4295, Vol: 50, Issue: 4, Page: 567-572
1997
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Article Description

Prostate-specific antigen (PSA) is commonly used as a marker for prostate disease. Prostate epithelium expresses both PSA and human glandular kallikrein (hK2) proteins, which share 80% sequence homology. The immunologic cross-reactivity of these two proteins could potentially interfere with determination of PSA levels in diagnoses of prostate cancer. We set out to determine the extent of this cross-reactivity for a panel of 10 anti-PSA monoclonal antibodies (mAbs).

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