Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
Cell, ISSN: 0092-8674, Vol: 89, Issue: 1, Page: 115-126
1997
- 324Citations
- 125Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations324
- Citation Indexes324
- 324
- CrossRef264
- Captures125
- Readers125
- 125
- Mentions1
- References1
- Wikipedia1
Article Description
The switch from short-term to long-term facilitation of the synapses between sensory and motor neurons mediating gill and tail withdrawal reflexes in Aplysia requires CREB-mediated transcription and new protein synthesis. We isolated several downstream genes, one of which encodes a neuron-specific ubiquitin C-terminal hydrolase. This rapidly induced gene encodes an enzyme that associates with the proteasome and increases its proteolytic activity. This regulated proteolysis is essential for long-term facilitation. Inhibiting the expression or function of the hydrolase blocks induction of long-term but not short-term facilitation. We suggest that the enhanced proteasome activity increases degradation of substrates that normally inhibit long-term facilitation. Thus, through induction of the hydrolase and the resulting up-regulation of the ubiquitin pathway, learning recruits a regulated form of proteolysis that removes inhibitory constraints on long-term memory storage.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0092867400801889; http://dx.doi.org/10.1016/s0092-8674(00)80188-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030887633&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9094720; http://linkinghub.elsevier.com/retrieve/pii/S0092867400801889; http://api.elsevier.com/content/article/PII:S0092867400801889?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0092867400801889?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/S0092867400801889; http://dx.doi.org/10.1016/s0092-8674%2800%2980188-9; https://dx.doi.org/10.1016/s0092-8674%2800%2980188-9
Elsevier BV
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