Cleavage of Chordin by Xolloid Metalloprotease Suggests a Role for Proteolytic Processing in the Regulation of Spemann Organizer Activity
Cell, ISSN: 0092-8674, Vol: 91, Issue: 3, Page: 407-416
1997
- 350Citations
- 114Captures
- 1Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations350
- Citation Indexes350
- 350
- CrossRef311
- Captures114
- Readers114
- 114
- Mentions1
- References1
- Wikipedia1
Article Description
The Xolloid secreted metalloprotease, a tolloid -related protein, was found to cleave Chordin and Chordin/BMP-4 complexes at two specific sites in biochemical experiments. Xolloid mRNA blocks secondary axes caused by chordin, but not by noggin, follistatin, or dominant-negative BMP receptor, mRNA injection. Xolloid-treated Chordin protein was unable to antagonize BMP activity. Furthermore, Xolloid digestion released biologically active BMPs from Chordin/BMP inactive complexes. Injection of dominant-negative Xolloid mRNA indicated that the in vivo function of Xolloid is to limit the extent of Spemann's organizer field. We propose that Xolloid regulates organizer function by a novel proteolytic mechanism involving a double inhibition pathway required to pattern the dorsoventral axis:
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0092867400804249; http://dx.doi.org/10.1016/s0092-8674(00)80424-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030665807&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/9363949; https://linkinghub.elsevier.com/retrieve/pii/S0092867400804249; http://linkinghub.elsevier.com/retrieve/pii/S0092867400804249; http://api.elsevier.com/content/article/PII:S0092867400804249?httpAccept=text/plain; http://api.elsevier.com/content/article/PII:S0092867400804249?httpAccept=text/xml
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know