The SR Protein SRp38 Represses Splicing in M Phase Cells
Cell, ISSN: 0092-8674, Vol: 111, Issue: 3, Page: 407-417
2002
- 172Citations
- 93Captures
- 2Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations172
- Citation Indexes172
- 172
- CrossRef168
- Captures93
- Readers93
- 93
- Mentions2
- References2
- Wikipedia2
Article Description
SR proteins constitute a family of pre-mRNA splicing factors that play important roles in both constitutive and regulated splicing. Here, we describe one member of the family, which we call SRp38, with unexpected properties. Unlike other SR proteins, SRp38 cannot activate splicing and is essentially inactive in splicing assays. However, dephosphorylation converts SRp38 to a potent, general repressor that inhibits splicing at an early step. To investigate the cellular function of SRp38, we examined its possible role in cell cycle control. We show first that splicing, like other steps in gene expression, is inhibited in extracts of mitotic cells. Strikingly, SRp38 was found to be dephosphorylated specifically in mitotic cells, and we show that dephosphorylated SRp38 is required for the observed splicing repression.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0092867402010383; http://dx.doi.org/10.1016/s0092-8674(02)01038-3; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0036848091&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/12419250; https://linkinghub.elsevier.com/retrieve/pii/S0092867402010383; http://linkinghub.elsevier.com/retrieve/pii/S0092867402010383; http://api.elsevier.com/content/article/PII:S0092867402010383?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0092867402010383?httpAccept=text/plain; http://dx.doi.org/10.1016/s0092-8674%2802%2901038-3; http://www.cell.com/cell/abstract/S0092-8674(02)01038-3?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867402010383%3Fshowall%3Dtrue; http://www.cell.com/article/S0092867402010383/abstract; http://www.cell.com/article/S0092867402010383/fulltext; http://www.cell.com/article/S0092867402010383/pdf
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know