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Active-Site Dynamics in RNA Polymerases

Cell, ISSN: 0092-8674, Vol: 116, Issue: 3, Page: 351-353
2004
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  • 38
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Review Description

New crystal structures of transcription complexes formed by bacteriophage T7 RNA polymerase reveal a nucleotide-addition cycle driven by active-site conformational changes similar to those observed in DNA polymerases, and suggest provocative hypotheses for the more complex multisubunit RNA polymerases of free-living organisms.

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