Antigen diversity in the bacterium B. hermsii through “Somatic” mutations in rearranged vmp genes
Cell, ISSN: 0092-8674, Vol: 78, Issue: 5, Page: 867-876
1994
- 75Citations
- 16Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations75
- Citation Indexes74
- 74
- CrossRef69
- Patent Family Citations1
- Patent Families1
- Captures16
- Readers16
- 16
Article Description
B. hermsii counters host immunity with multiphasic antigenic variation. This is conferred by interplasmidic and intraplasmidic rearrangements of vmp genes. In several independent events, activation of a silent vmp gene through intraplasmidic deletions but not interplasmidic recombinations was followed by the appearance at its 5′ end of multiple mutations that were not present in the silent gene. The prevalence of mutant alleles in postswitch populations increased during infections. Differences between the silent and expressed genes were at the same nucleotides at which vmp pseudogenes differed, suggesting these were templates for postswitch gene conversions. The mechanism of this bacterium to generate diversity, namely, intramolecular deletions followed by mutations in the rearranged gene, mirrors the strategy used by vertebrate hosts to eliminate it.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0092867494906424; http://dx.doi.org/10.1016/s0092-8674(94)90642-4; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027965079&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8087853; https://linkinghub.elsevier.com/retrieve/pii/S0092867494906424; http://linkinghub.elsevier.com/retrieve/pii/S0092867494906424; http://api.elsevier.com/content/article/PII:S0092867494906424?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0092867494906424?httpAccept=text/plain; http://dx.doi.org/10.1016/s0092-8674%2894%2990642-4; https://dx.doi.org/10.1016/s0092-8674%2894%2990642-4
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know