Diurnal variations of opioid peptides and synenkephalin in vitro release in the amygdala of kindled rats
Neuropeptides, ISSN: 0143-4179, Vol: 32, Issue: 3, Page: 293-299
1998
- 16Citations
- 13Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations16
- Citation Indexes16
- 16
- CrossRef11
- Captures13
- Readers13
- 13
Article Description
Pentylenetetrazol (PTZ) kindling was induced in male Wistar rats (250–300 g) by daily intraperitoneal injections of 35 mg/kg of the convulsant agent. Immunoreactive (IR)-Met-enkephalin (IR-ME), IR-Leu-enkephalin (IRLE), IR-heptapeptide (IR-HE), IR-octapeptide (IR-OC) and IR-synenkephalin (IR-Syn) in vitro release was measured from amygdala slices 24 h after the last stimulus, in groups of eight rats, every 4 h beginning at 08:00 h. Opioid peptides in vitro release displayed diurnal variations. IR-ME and IR-Syn showed maximal levels before the onset of darkness (16:00 h). IR-LE and IR-OC release was enhanced 4 h later (20:00 h), no changes were detected for IR-HE. These results show that endogenous opioid system (EOS) release displays diurnal variations. The peak for the analysed peptides was reached before and during the dark phase. It is suggested that EOS release enhancement in PTZ-kindled rats, seems to be due to a compensatory mechanism against the excitation induced by the blockade of the GABAergic transmission.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0143417998900518; http://dx.doi.org/10.1016/s0143-4179(98)90051-8; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0031859824&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/10189066; https://linkinghub.elsevier.com/retrieve/pii/S0143417998900518; http://linkinghub.elsevier.com/retrieve/pii/S0143417998900518; http://api.elsevier.com/content/article/PII:S0143417998900518?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:S0143417998900518?httpAccept=text/plain; http://dx.doi.org/10.1016/s0143-4179%2898%2990051-8; https://dx.doi.org/10.1016/s0143-4179%2898%2990051-8
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