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Serotonin receptor complexity: Relationships and roles

Pharmacochemistry Library, ISSN: 0165-7208, Vol: 24, Issue: C, Page: 85-97
1996
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Article Description

Many advances have been made in understanding the receptor substrates for the multiple actions of 5-HT. However, many fruitful areas of exploration remain ahead. The generation of receptor subtype selective approaches including ligands, radioligands, antibodies, antisense oligonucleotides, and transgenic animals has only begun. Even “well-characterized” receptors may hold new surprises. Further investigation of the molecular basis of ligand recognition are largely unexplored. Only a rudimentary understanding of signal transduction of these subtypes is extant. The next decade will likely see enormous progress in the understanding of this complex signaling system.

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