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The peptide-binding strategy of the MHC class II I-A molecules

Immunology Today, ISSN: 0167-5699, Vol: 19, Issue: 5, Page: 212-216
1998
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Article Description

Despite the importance of murine major histocompatibility complex (MHC) class II I-A molecules for immunological research, the overall peptide-binding specificities of I-A and the homologous human HLA-DQ molecules remain unresolved. Here, Boris Reizis and colleagues review current evidence suggesting that DQ/I-A molecules bind peptides with a different hierarchy of anchor positions than has been found in the well-characterized DR/I-E proteins.

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