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Chapter 21 Human herpesvirus-6 and bone marrow transplantation

Perspectives in Medical Virology, ISSN: 0168-7069, Vol: 4, Issue: C, Page: 281-301
1992
  • 16
    Citations
  • 0
    Usage
  • 10
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    16
    • Citation Indexes
      16
  • Captures
    10

Article Description

Marrow transplantation is being increasingly used for the treatment of a variety of diseases, including aplastic anemia, leukemia, and breast cancer. This chapter discusses a series of studies concerning the role of HHV-6 as a pathogen in marrow transplant patients. Human herpesvirus-6 (HHV-6) is a cause of severe interstitial pneumonitis, either directly, or in concert with other respiratory pathogens, in marrow transplants patients. In addition, a series of clinical and experimental observations have implicated HHV-6 marrow infection as an important cause of poor graft function in marrow transplant recipients. Serological and virological evaluation of marrow transplant patients has shown that HHV-6 reactivations are common in seropositive patients after marrow transplantation. Post-transplant HHV-6 primary infections occur and these infections frequently have peripheral and CNS clinical manifestations. This chapter also discusses that HHV-6 is an important pathogen in marrow transplant patients, and the two most common serious clinical manifestations of HHV-6 infection appear to be interstitial pneumonitis and poor marrow function.

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