Chapter 21 Human herpesvirus-6 and bone marrow transplantation
Perspectives in Medical Virology, ISSN: 0168-7069, Vol: 4, Issue: C, Page: 281-301
1992
- 16Citations
- 10Captures
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Article Description
Marrow transplantation is being increasingly used for the treatment of a variety of diseases, including aplastic anemia, leukemia, and breast cancer. This chapter discusses a series of studies concerning the role of HHV-6 as a pathogen in marrow transplant patients. Human herpesvirus-6 (HHV-6) is a cause of severe interstitial pneumonitis, either directly, or in concert with other respiratory pathogens, in marrow transplants patients. In addition, a series of clinical and experimental observations have implicated HHV-6 marrow infection as an important cause of poor graft function in marrow transplant recipients. Serological and virological evaluation of marrow transplant patients has shown that HHV-6 reactivations are common in seropositive patients after marrow transplantation. Post-transplant HHV-6 primary infections occur and these infections frequently have peripheral and CNS clinical manifestations. This chapter also discusses that HHV-6 is an important pathogen in marrow transplant patients, and the two most common serious clinical manifestations of HHV-6 infection appear to be interstitial pneumonitis and poor marrow function.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0168706908700727; http://dx.doi.org/10.1016/s0168-7069(08)70072-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77956938904&origin=inward; http://linkinghub.elsevier.com/retrieve/pii/S0168706908700727; https://linkinghub.elsevier.com/retrieve/pii/S0168706908700727; http://dx.doi.org/10.1016/s0168-7069%2808%2970072-7; https://dx.doi.org/10.1016/s0168-7069%2808%2970072-7
Elsevier BV
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