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Intracellular pH regulation and Na + /H + exchange activity in human hepatic stellate cells: effect of platelet-derived growth factor, insulin-like growth factor 1 and insulin

Journal of Hepatology, ISSN: 0168-8278, Vol: 34, Issue: 3, Page: 378-385
2001
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Article Description

Background/Aims : The Na + /H + exchanger is involved in rat hepatic stellate cell (HSC) proliferation induced by platelet-derived growth factor (PDGF). We therefore evaluated in human HSC: (1) the mechanisms of intracellular pH regulation; (2) the relationship between Na + /H + exchange activation and cell proliferation induced by PDGF, insulin-like growth factor 1 (IGF-1) and insulin.

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